Immunotherapy And Glioblastoma Multiforme
GBM is the most common primary brain tumor. As per the World Health
Organization (WHO), GBM is classified as grade IV glioma. GBM is invasive
and penetrates the adjoining brain tissue. Incidence is higher in case of
men and […]
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IMMUNOTHERAPY AND HEPATOCELLULAR CARCINOMA
Hepatocellular carcinoma (HCC) is considered the most common primary cancer
of the liver. HCC accounts for 90% of all liver cancers.HCC is the fifth
common cause of cancer in men and seventh in women worldwide. It is the
second most […]
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Immunotherapy And Gastroenteropancreatic Neuroendocrine Tumor
Gastroenteropancreatic Neuroendocrine Tumor (GEP-NET) originates from the
hormone producing cells of the gut along with rectum and pancreas.GEP-NET
represents 75% of all neuroendocrine tumors (NETs). […]
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IMMUNOTHERAPY AND MALIGNANT PLEURAL MESOTHELIOMA
Malignant pleural mesothelioma is an aggressive type of cancer in which
cancerous cells are found in the lining of the abdomen or chest that occurs
due to asbestos exposure in the mesothelium. According to the National
Cancer Institute's […]
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IMMUNOTHERAPY AND PANCREATIC CANCER
Integrative Gastroenterology and Hepatology Immunotherapy and Pancreatic
Cancer Allen T* , Shoja G and Court NB Global Allied Pharmaceuticals, Center
for Excellence in Research and Development, USA * Correspondence: Timothy
Allen, Global Allied Pharmaceuticals, Center for Excellence in Research and
[…]
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Immunotherapy and Meningioma Timothy Allen*, Ariel Sheikkhon, Shoja E Razavi,
Naveed Basha Court Global Allied Pharmaceuticals, Center for Excellence in
Research and Development, USA. timallenmed69@gmail.com *Corresponding
Author: Timothy Allen, Global Allied Pharmaceuticals, Center for Excellence
in Research and Development, 160 […]
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Immunotherapy And Penis Cancer
Abstract Penis cancer, a cancerous disease in which malignant cells appear in
the tissues of the penis. It occurs in the uncircumcised older men. It is
recognized by at least two independent carcinogenic routes: virus and
non-virus induced. The penis […]
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Download Abstract Diffuse large B-cell lymphoma (DLBCL) in the most common
type of non-Hodgkin's lymphoma (NHL) in developed world, so far and
approximately 60,000 new non-Hodgkin lymphoma (NHL) cases and 20,000 deaths
have been estimated in the United States for […]
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Download Abstract Diffuse large B cell lymphoma (DLBCL) in the most common
type of non-Hodgkin's lymphoma (NHL) in developed world, so far and
approximately 60,000 new non-Hodgkin lymphoma (NHL) cases and 20,000 deaths
have been estimated in the United States […]
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Abstract Download Worldwide incidence of malignant melanoma has been
constantly increasing during the last years. Surgical excision is effective
when primary tumors are thin with thickness of less than 1milli meter and
there is no evidence of metastases. At later […]
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Gastrointestinal Events Associated With Ipilimumab And Combination Therapies
Download Gastrointestinal Events Associated with Ipilimumab, Pazopanib, Anti
PD1- Antibody and Their Management: Single and Combination Therapies Timothy
Allen, MD, Ph.D1*, Giridhar M.N.V, MD,MBA1*, Ghazaleh Shoja E Razavi MD2
1Global Allied Pharmaceutical, Center for Excellence in Research &
Development, USA. […]
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PROTEASOME INHIBITION IN LYMPHOPROLIFERATIVE DISORDER.
Abstract Download Proteasomes are multi-subunit protein complexes, which
present numerous targets for therapeutic interference. The most commonly
used proteasome is 26S proteasome, which contains one 20S proteolytic core
subunit and two 19S regulatory cap subunits. There are three different types
[…]
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Toxicities Associated With Antibody Drug Conjugates
Abstract Download Conventional chemotherapeutic agents, in the treatment of
several cancers, lack specificity, resulting in toxicities to normal tissues
and poor therapeutic index. Antibody-based immunoconjugates are specifically
targeted monoclonal antibodies that deliver the cytotoxic agent to the
target cell. When […]
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Mechanisms Of Drug Resistance In Glioblastoma Multiforme.
Abstract Download Glioblastoma multiforme (GBM) is a group of low-grade as
well as high-grade brain tumors that originate from the glia;neuroglial
cells and are the most common and crucial brain tumor, specially in adults.
The main causes are deemed to […]
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Abstract Download Blockade of various immune targets such as cytotoxic
T-lymphocyte antigen-4 and Programmed cell death leads to immune-mediated
tumor regression and immune-related adverse events, predominantly
gastrointestinal events including diarrhea and colitis. The current review
is done to understand the […]
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A Review Of Newer Technologies In Development Of Nanomedicines For Cancers.
Abstract Download Cancer is the leading cause of morbidity and mortality
worldwide. Advances in nanotechnology have contributed to the development of
nanoparticles used for medical applications and optimized therapy. Due to
unique features of nanoparticles, like a large surface area, […]
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Safety And Efficacy Of Peptide Based Vaccines.
Download Abstract A vaccine is a biological preparation which produces
immunity from diseases or infections. A vaccine can be administeredby either
of the route, orally (through mouth) or through needle injections or by
aerosol [1]. Vaccine development process involves induction […]
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Role Of Vascular Endothelial Growth Factor Receptor Inhibitors In Refractory Cervical Cancer.
Download Abstract This review article focuses on the past and future aspects
of vascular endothelial growth factor inhibitors in Cervical Cancer.Vascular
endothelial growth factor (VEGF)-mediated angiogenesis is considered to play
a vital function in the tumor development and metastasis. Therefore,
[…]
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Immunotherapy In Metastatic Renal Cell Carcinoma.
Download Abstract Immunotherapy plays a crucial role in the treatment of
patients with renal cell carcinoma. Metastatic renal cell carcinoma (MRCC)
remains a therapeutic challenge because of its strong resistance to both
chemotherapy and radiation therapy. This review explains the […]
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Anti-Inflammatory Agents And Their Role In Atherosclerosis.
Download Abstract Atherosclerosis is a chronic disease, with the process of
narrowing and hardening of arteries and accumulation of plaques. Normally,
atherosclerosis is related with other cardiovascular disease such as
peripheral vascular disease, heart attack, and stroke. An inflammation plays
[…]
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Complementary Medicines And Cancer.
Download Abstract A great strength of patients use complementary medicine,
which is an adjuvant to the conventional treatment because complementary
medicine is an integrative approach. Conventional treatments have some
harmful effects for patients, but many patients use complementary medicine,
along […]
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Mechanisms of Resistance to Rituximab in B-cell Lymphoma.
Rituximab or Anti-CD20, is a chimeric monoclonal antibody (MoAb)that has
become a ubiquitous component for improved therapeutic options for patients
with B-cell non-Hodgkin lymphoma (B-NHL)and other known hematological
malignancies. The MoAbs has the direct antiproliferative effect on the B
cells in vitro. […]
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A Review Article On Emerging Role Of Hybrid Molecules In Treatment Of Breast Cancer.
Abstract Download Breast cancer is the most common cancer in women; however,
many of them relapse following primary treatment. The pattern of treating
breast cancer has been changed over last decades. Dendritic Cell/tumour
hybrid, hydroxyphenyltyrosinamide- chlorambucil, SNIPER, hybrid
radiopharmaceutical and […]
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Abstract Download The article discuss about the role of peptide vaccine in
Cancer therapy. A peptide vaccine is a type of vaccine in which a peptide of
the original pathogen is used to immunize an organism. Key words:Vaccines,
Angiogenesis, […]
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Growth Factor As A Supportive Treatment In Chemotherapy.
Abstract Download Even after a lot of advancements have been made in the
treatment patterns of the various malignancies, there are still a number of
dose-limiting toxicities associated with chemotherapy. Most of these
toxicities are of hematological nature. Hence, there […]
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Principles Of Nutritional Support In Cancer Patients
Download Abstract Cancer patients are already compromised on nutrition. A
good nutrition plays a very important role in cancer patient. Malnutrition
delays overall recovery of patient from cancer treatment and may lead to
further serious complications. On the other hand, […]
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A Review Article On Neuropathic Pain.
Abstract Download Neuropathic pain is a pathological pain caused due to
damaged nerves, as a result of an injury on the somatosensory system. Its
effect is mainly on the outside of the brain and spinal cord. Therefore, it
is mainly […]
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Download Abstract Cancer is one of the highly prevalent diseases worldwide
that affects different organs of the body, leading to the rapid and
uncontrolled division of cells, forming a mass of tumor cells. There are
several conventional therapies available for […]
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Abstract Download Different neurological disorders, including alterations of
peripheral nerves, multiple sclerosis (MS), optic neuritis (ON), acute
transverse myelitis (ATM) and posterior reversible encephalopathy syndrome
(PRES) can be associated with some types of immunotherapy. Likewise,
anti-tumor necrosis factor alpha (TNF-?) […]
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COX-2 Inhibitors And Their Role In Cancer Prevention And Treatment.
Abstract: Download The various steps in the process of carcinogenesis take
many years, which contributes to several opportunities for intervention to
inhibit growth of the disease. The reduction in the risk, associated with
cancer may be done by few effective […]
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Cancer-Related Fatigue And Its Management.
Download Abstract Fatigue is the most common symptom found in the cancer
patients, with a prevalence of more than 60%, as reported in the major part
of various studies. This paper mainly reviews the management of the cancer
related fatigue. […]
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Download Abstract Fatigue is the most common symptom found in the cancer
patients, with a prevalence of more than 60%, as reported in the major part
of various studies. This paper mainly reviews the management of the cancer
related fatigue. […]
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Role Of Immunotherapy For H. Pylori In Gastric Cancer.
Download Abstract Gastric cancer is a well-known challenging health problem
in the world, which has been deemed to be associated with Helicobacter
pylori (H. pylori). H. pylori avoid the endogenous immune reactions. An
effective production of antibody against H. pylori […]
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Immunotherapeutic Approach To Squamous Cell Carcinoma Of The Head And Neck.
Download Abstract Head and neck cancers make up of 3-5% of cancer diagnoses
in the United States. The most common occur in the squamous cells of the
head and neck. Immunotherapy is an alternative to chemotherapy and radiation
therapy to […]
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New Targets In Treatment Of Myelodysplastic Syndrome
Download Abstract Myelodysplastic syndrome is a heterogeneous category of
hematologic disorders that has been recognized primarily by abnormal
morphology and number of blood cells originating from hematopoietic stem
cells in the bone marrow based on the genetic as well as […]
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Targeted Therapy For Chondrosarcoma.
Download Abstract Primary malignant bone tumors occur 1/100,000, of which
17-24% consists of chondrosarcoma. Unfortunately, the cause is unknown, but
there have been several risks factors accused of causing the disease.
Targeted therapy is a cancer specific treatment alternative to […]
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Therapeutic Approach To Chordomas
Download Abstract Chordomas are neoplasms that come from the notochord's
cellular remnants. Immunotherapy is a cancer treatment alternative to
chemotherapy and radiation therapy. Its goal is to use a patient's own
immune system to fight the tumor. The immune system […]
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Novel Targets And Breast Cancer Treatment.
Download Abstract Breast cancer is the second most common cancer in women,
after skin cancer. One out of every 8 woman in the United States will
develop breast cancer. It can be caused by genetic mutations, using certain
medicines, or […]
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Novel Approaches In Treatment Of Adult AML
Download Abstract Acute myeloid leukemia (AML) is cancer of the blood cells.
This cancer specifically affects red blood cells, platelet forming cells and
other white blood cells in the body; its incidence is very low in the United
States with […]
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Emerging Role Of Immunotherapy In Breast Cancer.
Download Abstract Breast cancer is the second most common cancer in women,
after skin cancer. One out of every 8 woman in the United States will
develop breast cancer. It can be caused by genetic mutations, using certain
medicines, or […]
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Immunotherapeutic Approach To Osteosarcoma.
Download Abstract Osteosarcoma is a rare form of cancer that account for less
than 0.2% of all cancers diagnosed in the United States. Unfortunately, the
cause is unknown, but there have been several risks factors accused of
causing the disease […]
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Immunotherapeutic Approach To Anal Cancer.
Download Abstract Anal cancer is a rare disease that accounts for 0.4% of all
cancer diagnoses in the United States. Its incidence has increased by 2.2%
annually. The risk factors associated with anal cancer are Human Papilloma
Virus (HPV), Human […]
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Therapeutic approach to CML in TKI era.
Download Abstract Chronic myeloid leukemia is a cancer that affects the cells
of the bone marrow. These effected cells can grow and divide rapidly and
spill into other parts of the body. It is relatively prevalent in the United
States […]
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Immunotherapy and Cervical Cancer.
Download Abstract Cervical cancer is a leading cause of death worldwide, as
per statistical analysis, it is the seventh most common cancer. Majority of
the cervical cancers are caused by persistent infections with specific types
of the human papillomavirus (HPV) […]
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HIV AND HTLV1 ASSOCIATED LYMPHOMA & IMMUNOTHERAPY.
People with HIV infections are at increased risk for lymphoma. It is a
disease in which malignant cells form in the lymphatic system of patients
who have acquired immunodeficiency syndrome. The use of highly active
anti-retroviral therapy […]
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Immunotherapy and colon cancer.
Colon cancer is the third most commonly diagnosed cancer and the second
leading cause of cancer death in both men and women in the U.S. The exact
cause of the colonic cancer is still unknown but has several risk factors
like the age […]
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Immunotherapy in Hodgkin Lymphoma.
Hodgkin's lymphoma is a lymphocyte cancer, with a 9,190 new cases per year in
the U.S. It is sub-divided into two main categories: the Classical Hodgkin
Lymphoma "CHL" and the Nodular lymphocyte predominant Hodgkin lymphoma
"NLPHL". […]
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Role of Immunotherapy in Post Transplantation Lymphoproliferative Disorders.
Post transplantation Lymphoproliferative Disorder is the most severe
complication of both solid organ transplantation and hematopoietic stem cell
transplantation. It arises in 1-15% of transplanted patients and involves
malignant and uncontrolled […]
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Immunotherapy and polycythemia vera.
Polycythemia vera (PV) is a chronic myeloproliferative disorder characterized
by abnormal growth of erythroid precursors in the bone marrow. Almost all
patients with PV, around 97%, have a mutation in Janus kinase 2 (JAK2). It
is through the […]
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Immunotherapeutic Approach to Laryngeal Cancer.
Laryngeal cancer is a rare cancer, accounts for 12,630 new cases in 2014 out
of a total number of 1,665,540 new cancer cases in the United States. It is
mostly Squamous in origin as the rest of head and neck tumors. Immunotherapy
is an alternative […]
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Immunotherapeutic Approach to Oropharyngeal Cancer.
Oropharyngeal cancer accounts for more than 13000 new cases in the US, which
is more common in older men, and male:female ratio is 2.7:1. Immunotherapy
is an alternative to chemotherapy and radiation therapy to treat cancer. It
is utilized to […]
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Immunotherapeutic approach to nasopharyngeal cancer.
Nasopharyngeal cancer (NPC) is a rare cancer in most populations like the
Caucasians in North America; it is a leading form of cancer in a few
well-defined populations, including natives of southern China, Southeast
Asia, the Arctic, and the Middle […]
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Application of molecular targeted therapy for refractory metastatic thyroid cancers
Thyroid cancer is one of the leading causes of death worldwide. There have
been several risks factors linked with thyroid cancer such as genetics,
exposure to radiation, body weight and insulin resistance. Poorly
differentiated and recurrent […]
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Immunotherapy and target therapy in non-Hodgkin's lymphoma.
Non-Hodgkins's lymphomas (NHL) are a heterogenous group of B and T cell
malignancies primarily involving lymphatic system. NHL is fifth leading
cause of cancer mortality. Due to evolving science and better understanding
of pathophysiology of the […]
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Immunotherapy in basal cell carcinoma.
Basal cell carcinoma (BCC), primarily affecting the photo-exposed areas of
the body, is one of the most common skin cancers accounting for about 75% of
all skin cancers. Various genetic and molecular factors, in addition to the
exposure to […]
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Immunotherapy for cancers of the biliary tract.
Cancer of the biliary tract (CBT) are relatively uncommon types of tumors.
They are frequently diagnosed at a late stage with weak response to
conventional therapies such as chemotherapy and radiotherapy. Thus a totally
new and different treatment […]
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Immunotherapy and Uterine Cancer.
Uterine cancer is the most common gynecologic malignancy diagnosed among
women in the United States. Globally, the incidence is highest in North
America and lowest in South Central Asia. Current standard therapy for
uterine cancer most commonly […]
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Immunotherapy and Acute Lymphoblastic Leukemia.
Acute lymphoblastic leukemia is a serious type of cancer that originates from
the development and differentiation o the early version of lymphocytes in
the bone marrow. With the advent of new technologies and discoveries, novel
therapeutics were […]
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Immunotherapy and myeliod metaplasia.
The past few decades have witnessed significant advances in our understanding
of the etiology, diagnosis and treatment of Myeloproliferative disorders
(MPDs). Although the causes of chronic MPDs remain unknown, Janus kinase 2
(JAK 2) gene mutation […]
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New Targets in Treating Multiple Myeloma.
Multiple myeloma is one of the chronic lymph proliferative disorders that
mainly affect elderly population. Despite the fact that various lines of
treatment have been suggested and approved for this type of hematologic
malignancy and autologous stem […]
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Social support, quality of life and mental health status in breast cancer patients.
Objective: In this study, Objective was to assess the social support, quality
of life and mental health status in breast cancer patients. Different
literatures have highlighted the breast cancer's impact on mental health,
quality of life, financial […]
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Immunotherapy and small cell lung cancer (SCLC).
Lung cancer is the leading cause of cancer death worldwide. Lung cancers are
mainly of two types: non-small cell lung cancer (NSCLC) and small cell lung
cancer (SCLC). Small cell lung cancer accounts for about 15% of all the
types of lung cancers […]
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Immunotherapy and squamous cell carcinoma.
Squamous cell carcinoma (SCC) develops from keratinocytes. As per the
statistical analysis, it is the second most frequent skin cancer after Basal
cell carcinoma among non-melanoma skin cancers and its incidences are more
than death cases . […]
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The histogenesis of Ewing Sarcoma.
Ewing Sarcoma is the second most frequent malignant bone tumor in adolescents
and young adults. The majority of Ewing sarcoma arises in the bone, but
15-20% of Ewing sarcoma originates in the soft tissue surrounding bones
[…]
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Immunotherapy and urinary bladder cancer.
Bladder cancer is a type of cancer, which arises from the epithelial lining
(urothelium) of the urinary bladder due to the uncontrolled growth of
abnormal cells in the bladder. Transitional cell carcinoma (TCC) is the most
common type of cancer […]
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Oral Mucositis refers to oral mucosa erythematous and ulcerative lesions and
is caused by radiation dispensed in the treatment of malignant tumors of the
head and neck. Propolis shows several biological activities such as
antimicrobial and […]
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Randomized clinical study of SCP pacliataxel in patients with advanced cervical cancer.
Introduction: Cervical cancer is the second most commonly occurring cancer in
women, and it is responsible for 15% of all female malignancies. Metastatic
cervical cancer occurs in 15-61% of cases, and available oncology therapies
do not offer the […]
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Objective: Doxorubicin has been the mainstay of treatment for advanced STS.
However, the conventional formulation of doxorubicin has not been used
clinically, due to poor penetration of the natural physiologic barriers,
poor water solubility and […]
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Introduction: Cervical cancer is the second most commonly occurring cancer in
women, and it is responsible for 15% of all female malignancies. Metastatic
cervical cancer occurs in 15-61% of cases, and available oncology therapies
do not offer the […]
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Advances and Challenges in the Development of an Epstein-Barr Virus Vaccine.
Objective: The development of a vaccine against Epstein-Barr Virus (EBV) is
crucial due to its association with various cancers and diseases such as
Burkitt lymphoma, Hodgkin lymphoma, nasopharyngeal cancer, and multiple
sclerosis.[…]
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Artificial: intelligence (AI) is rapidly transforming healthcare, offering
promising solutions to reduce costs and improve patient outcomes. This paper
explores the diverse applications of AI in medicine, from diagnosis to drug
discovery and clinical decision support. […]
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Stem Cell Therapies for Chronic Wound Management: A Comprehensive Review
Artificial: Chronic wounds, particularly prevalent among patients with
diabetes and peripheral arterial disease, pose significant health challenges
and financial burdens, with treatment costs exceeding $22 billion annually.
Conventional treatment methods, including autografts and debridement, often
involve painful procedures and limited efficacy.[…]
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Advances in Hair Loss Treatment and the Use of Stem Cells
Hair follicle regeneration is vital to treat those suffering from alopecia. To
accomplish this, various markers can be used to determine the causes of alopecia
and subsequent treatment methods—these range from diagnostic, prognostic, and
molecular markers to forms of histopathological examination. […]
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Ethical Dissemination of Clinical Information through Advertising and Citation of Research Papers
The dissemination of clinical information is crucial for advancing medical
knowledge and improving patient care. Ethical advertising and the citation of
clinical research papers play significant roles in this process.. […]
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A Comprehensive Diagnostic and Treatment Framework for Pancreatic Cancer Patients with Comorbidities
Pancreatic cancer remains a challenging malignancy with a high mortality
rate. Comorbidities such as chronic pancreatitis, diabetes
mellitus, obesity, and metabolic syndrome exacerbate diagnostic and
treatment challenges, significantly influencing outcomes. […]
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Adoption and Case Studies of Generative AI Tools in Medical Writing
Generative AI (GenAI) tools are revolutionizing medical writing in the pharmaceutical and medical device industries.[…]
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A Comprehensive Diagnostic and Treatment Framework for Cervical Cancer Patients with Comorbidities
Cervical cancer is the fourth most common cancer among women
globally, accounting for approximately 604,000 new cases and
342,000 deaths annually, with the majority occurring in low- and
middle-income countries. […]
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Cognitive decline is influenced by various factors, including diet, oral and gut microbiome health, vascular function, and systemic inflammation. […]
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