Abstract
Squamous cell carcinoma (SCC) develops from keratinocytes. As per the statistical analysis, it is the second most frequent skin cancer after Basal cell carcinoma among non-melanoma skin cancers and its incidences are more than death cases . Australia has the highest incidence as compared to the rest of the world. This type of cancer is caused primarily by the exposure to the UV radiation, coming from the sun. SCC develops due to the alteration in the DNA of the squamous cells present in the outer skin layer. In this carcinoma, an early stage shows replacement of normal epithelial cells by atypical squamous cells throughout the epidermis, resulting in abnormal growth. Immunotherapy has shown to be a promising development in the past few years. The recent activities have increased our understanding of the tumour microenvironment, various immunotherapeutic modalities or combination therapy (like chemotherapy with immunotherapy). The complete perspective of the immunotherapy treatment has not been realized yet. Additionally, the effects of such modalities in combination with immunotherapy in cancer patients are still explorat