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Anti-inflammatory agents and their role in atherosclerosis.


Atherosclerosis is a chronic disease, with the process of narrowing and hardening of arteries and accumulation of plaques. Normally, atherosclerosis is related with other cardiovascular disease such as peripheral vascular disease, heart attack, and stroke. An inflammation plays a key role in the progression and development of atherosclerosis. Majorly dead cells and oxidized form of low density lipoproteins (oxLDL) are present as pro-inflammatory cytokines.Various therapeutic agents of anti-inflammatory nature has been evaluated for the treatment of atherosclerosis. Few agents have presented beneficial anti-inflammatory effects on the atherosclerosis and suppress the risk of other cardiovascular disease. The anti-inflammatory properties of niacin, statins, flavonoids, and aspirin are the most satisfactory effects for the treatment of atherosclerosis.The risk of atherosclerosis can be reduced by lowering the lipid level in the body with the help of anti-inflammatory agents, and to avoid other risk factor such as smoking. This review paper will provide an insight of anti-inflammatory agents which are in current use and arrange a prospect, on the challenges against the development of drugs which target inflammation.

Key words: Atherosclerosis, anti-inflammatory agents, inflammation, therapies, mechanism of anti-inflammatory agents, pro-inflammatory cytokines.

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