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Growth Factor As A Supportive Treatment In Chemotherapy.


Even after a lot of advancements have been made in the treatment patterns of the various malignancies, there are still a number of dose-limiting toxicities associated with chemotherapy. Most of these toxicities are of hematological nature. Hence, there is always a need of supportive care treatment to assist these cytotoxic drugs. The main aim of supportive care is not only to relieve the adverse effects but also to improve the living quality of the sufferer. Hence, the pharmacologic agents that can readily improve the recovery of hematological functions can be the potential candidate for supportive care treatment. Growth factors are peptides having low molecular weight and are found to be active in the stimulation of cell proliferation, regulation of embryonic development and cellular differentiation. These small molecules are available as a supportive treatment to control and decrease the cytopenia, resultant from toxicity of chemotherapeutic treatment on bone marrow of cancer patients. These growth factors may include GM-CSF, G-CSF, and erythropoietin. All these growth factors can be utilized as a supportive care treatment in different diseases that may be induced after chemotherapy or after transplantations. The complete indications and the applications of these therapeutic agents as the supportive care treatment have been discussed in this article.

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